RapamycinFungusV1, Main, Exploration, bibRecord, 000C43

Piperine metabolically regulates peritoneal resident macrophages to potentiate their functions against bacterial infection.

Identifieur interne : 000C43 ( Main/Exploration ); précédent : 000C42; suivant : 000C44

Piperine metabolically regulates peritoneal resident macrophages to potentiate their functions against bacterial infection.

Auteurs : Hao Pan [République populaire de Chine] ; Li-Hui Xu [République populaire de Chine] ; Mei-Yun Huang [République populaire de Chine] ; Qing-Bing Zha [République populaire de Chine] ; Gao-Xiang Zhao [République populaire de Chine] ; Xiao-Feng Hou [République populaire de Chine] ; Zi-Jian Shi [République populaire de Chine] ; Qiu-Ru Lin [République populaire de Chine] ; Dong-Yun Ouyang [République populaire de Chine] ; Xian-Hui He [République populaire de Chine]

Source :

Oncotarget [ 1949-2553 ] ; 2015.

RBID : pubmed:26439699

Descripteurs français

English descriptors

KwdEn :
- Alkaloids (pharmacology), Amino Acids (metabolism), Animals (MeSH), Anti-Bacterial Agents (pharmacology), Apoptosis (drug effects), Benzodioxoles (pharmacology), Disease Models, Animal (MeSH), Escherichia coli (drug effects), Escherichia coli (immunology), Escherichia coli (pathogenicity), Escherichia coli Infections (immunology), Escherichia coli Infections (metabolism), Escherichia coli Infections (microbiology), Escherichia coli Infections (pathology), Escherichia coli Infections (prevention & control), Female (MeSH), Fusion Regulatory Protein 1, Heavy Chain (metabolism), HeLa Cells (MeSH), Humans (MeSH), Immunity, Innate (drug effects), Inflammation Mediators (metabolism), Interleukin-6 (metabolism), Large Neutral Amino Acid-Transporter 1 (genetics), Large Neutral Amino Acid-Transporter 1 (metabolism), Lipopolysaccharides (pharmacology), Macrophage Activation (drug effects), Macrophages, Peritoneal (drug effects), Macrophages, Peritoneal (immunology), Macrophages, Peritoneal (metabolism), Macrophages, Peritoneal (microbiology), Macrophages, Peritoneal (pathology), Male (MeSH), Mechanistic Target of Rapamycin Complex 1 (MeSH), Mice (MeSH), Mice, Inbred C57BL (MeSH), Multiprotein Complexes (metabolism), Phagocytosis (drug effects), Piperidines (pharmacology), Polyunsaturated Alkamides (pharmacology), RAW 264.7 Cells (MeSH), RNA Interference (MeSH), Signal Transduction (drug effects), TOR Serine-Threonine Kinases (metabolism), Time Factors (MeSH), Transfection (MeSH), Tumor Necrosis Factor-alpha (metabolism).
MESH :
- chemical , genetics : Large Neutral Amino Acid-Transporter 1.
- chemical , metabolism : Amino Acids, Fusion Regulatory Protein 1, Heavy Chain, Inflammation Mediators, Interleukin-6, Large Neutral Amino Acid-Transporter 1, Multiprotein Complexes, TOR Serine-Threonine Kinases, Tumor Necrosis Factor-alpha.
- chemical , pharmacology : Alkaloids, Anti-Bacterial Agents, Benzodioxoles, Lipopolysaccharides, Piperidines, Polyunsaturated Alkamides.
- drug effects : Apoptosis, Escherichia coli, Immunity, Innate, Macrophage Activation, Macrophages, Peritoneal, Phagocytosis, Signal Transduction.
- immunology : Escherichia coli, Escherichia coli Infections, Macrophages, Peritoneal.
- metabolism : Escherichia coli Infections, Macrophages, Peritoneal.
- microbiology : Escherichia coli Infections, Macrophages, Peritoneal.
- pathogenicity : Escherichia coli.
- pathology : Escherichia coli Infections, Macrophages, Peritoneal.
- prevention & control : Escherichia coli Infections.
- Animals, Disease Models, Animal, Female, HeLa Cells, Humans, Male, Mechanistic Target of Rapamycin Complex 1, Mice, Mice, Inbred C57BL, RAW 264.7 Cells, RNA Interference, Time Factors, Transfection.

Abstract

Pepper, a daily-used seasoning for promoting appetite, is widely used in folk medicine for treating gastrointestinal diseases. Piperine is the major alkaloid in pepper and possesses a wide range of pharmacological activities. However, the mechanism for linking metabolic and medicinal activities of piperine remains unknown. Here we report that piperine robustly boosts mTORC1 activity by recruiting more system L1 amino acid transporter (SLC7A5/SLC3A2) to the cell membrane, thus promoting amino acid metabolism. Piperine-induced increase of mTORC1 activity in resident peritoneal macrophages (pMΦs) is correlated with enhanced production of IL-6 and TNF-α upon LPS stimulation. Such an enhancement of cytokine production could be abrogated by inhibitors of the mTOR signaling pathway, indicating mTOR's action in this process. Moreover, piperine treatment protected resident pMΦs from bacterium-induced apoptosis and disappearance, and increased their bacterial phagocytic ability. Consequently, piperine administration conferred mice resistance against bacterial infection and even sepsis. Our data highlight that piperine has the capacity to metabolically reprogram peritoneal resident macrophages to fortify their innate functions against bacterial infection.

DOI: 10.18632/oncotarget.5957
PubMed: 26439699
PubMed Central: PMC4741706

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000B69
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Le document en format XML

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<author><name sortKey="Shi, Zi Jian" sort="Shi, Zi Jian" uniqKey="Shi Z" first="Zi-Jian" last="Shi">Zi-Jian Shi</name>
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<author><name sortKey="Xu, Li Hui" sort="Xu, Li Hui" uniqKey="Xu L" first="Li-Hui" last="Xu">Li-Hui Xu</name>
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<country xml:lang="fr">République populaire de Chine</country>
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<affiliation wicri:level="3"><nlm:affiliation>Department of Fetal Medicine, the First Affiliated Hospital of Jinan University, Guangzhou, China.</nlm:affiliation>
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</placeName>
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<author><name sortKey="Shi, Zi Jian" sort="Shi, Zi Jian" uniqKey="Shi Z" first="Zi-Jian" last="Shi">Zi-Jian Shi</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Fetal Medicine, the First Affiliated Hospital of Jinan University, Guangzhou, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Fetal Medicine, the First Affiliated Hospital of Jinan University, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
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<author><name sortKey="Lin, Qiu Ru" sort="Lin, Qiu Ru" uniqKey="Lin Q" first="Qiu-Ru" last="Lin">Qiu-Ru Lin</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Immunobiology, College of Life Science and Technology, Jinan University, Guangzhou, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Immunobiology, College of Life Science and Technology, Jinan University, Guangzhou</wicri:regionArea>
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<author><name sortKey="Ouyang, Dong Yun" sort="Ouyang, Dong Yun" uniqKey="Ouyang D" first="Dong-Yun" last="Ouyang">Dong-Yun Ouyang</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Immunobiology, College of Life Science and Technology, Jinan University, Guangzhou, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Immunobiology, College of Life Science and Technology, Jinan University, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
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<author><name sortKey="He, Xian Hui" sort="He, Xian Hui" uniqKey="He X" first="Xian-Hui" last="He">Xian-Hui He</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Immunobiology, College of Life Science and Technology, Jinan University, Guangzhou, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Immunobiology, College of Life Science and Technology, Jinan University, Guangzhou</wicri:regionArea>
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<region type="province">Guangdong</region>
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<series><title level="j">Oncotarget</title>
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<imprint><date when="2015" type="published">2015</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alkaloids (pharmacology)</term>
<term>Amino Acids (metabolism)</term>
<term>Animals (MeSH)</term>
<term>Anti-Bacterial Agents (pharmacology)</term>
<term>Apoptosis (drug effects)</term>
<term>Benzodioxoles (pharmacology)</term>
<term>Disease Models, Animal (MeSH)</term>
<term>Escherichia coli (drug effects)</term>
<term>Escherichia coli (immunology)</term>
<term>Escherichia coli (pathogenicity)</term>
<term>Escherichia coli Infections (immunology)</term>
<term>Escherichia coli Infections (metabolism)</term>
<term>Escherichia coli Infections (microbiology)</term>
<term>Escherichia coli Infections (pathology)</term>
<term>Escherichia coli Infections (prevention & control)</term>
<term>Female (MeSH)</term>
<term>Fusion Regulatory Protein 1, Heavy Chain (metabolism)</term>
<term>HeLa Cells (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Immunity, Innate (drug effects)</term>
<term>Inflammation Mediators (metabolism)</term>
<term>Interleukin-6 (metabolism)</term>
<term>Large Neutral Amino Acid-Transporter 1 (genetics)</term>
<term>Large Neutral Amino Acid-Transporter 1 (metabolism)</term>
<term>Lipopolysaccharides (pharmacology)</term>
<term>Macrophage Activation (drug effects)</term>
<term>Macrophages, Peritoneal (drug effects)</term>
<term>Macrophages, Peritoneal (immunology)</term>
<term>Macrophages, Peritoneal (metabolism)</term>
<term>Macrophages, Peritoneal (microbiology)</term>
<term>Macrophages, Peritoneal (pathology)</term>
<term>Male (MeSH)</term>
<term>Mechanistic Target of Rapamycin Complex 1 (MeSH)</term>
<term>Mice (MeSH)</term>
<term>Mice, Inbred C57BL (MeSH)</term>
<term>Multiprotein Complexes (metabolism)</term>
<term>Phagocytosis (drug effects)</term>
<term>Piperidines (pharmacology)</term>
<term>Polyunsaturated Alkamides (pharmacology)</term>
<term>RAW 264.7 Cells (MeSH)</term>
<term>RNA Interference (MeSH)</term>
<term>Signal Transduction (drug effects)</term>
<term>TOR Serine-Threonine Kinases (metabolism)</term>
<term>Time Factors (MeSH)</term>
<term>Transfection (MeSH)</term>
<term>Tumor Necrosis Factor-alpha (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Acides aminés (métabolisme)</term>
<term>Activation des macrophages (effets des médicaments et des substances chimiques)</term>
<term>Alcaloïdes (pharmacologie)</term>
<term>Amides gras polyinsaturés N-alkylés (pharmacologie)</term>
<term>Animaux (MeSH)</term>
<term>Antibactériens (pharmacologie)</term>
<term>Apoptose (effets des médicaments et des substances chimiques)</term>
<term>Benzodioxoles (pharmacologie)</term>
<term>Cellules HeLa (MeSH)</term>
<term>Cellules RAW 264.7 (MeSH)</term>
<term>Chaine lourde de l'antigène CD98 (métabolisme)</term>
<term>Complexe-1 cible mécanistique de la rapamycine (MeSH)</term>
<term>Complexes multiprotéiques (métabolisme)</term>
<term>Escherichia coli (effets des médicaments et des substances chimiques)</term>
<term>Escherichia coli (immunologie)</term>
<term>Escherichia coli (pathogénicité)</term>
<term>Facteur de nécrose tumorale alpha (métabolisme)</term>
<term>Facteurs temps (MeSH)</term>
<term>Femelle (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Immunité innée (effets des médicaments et des substances chimiques)</term>
<term>Infections à Escherichia coli (anatomopathologie)</term>
<term>Infections à Escherichia coli (immunologie)</term>
<term>Infections à Escherichia coli (microbiologie)</term>
<term>Infections à Escherichia coli (métabolisme)</term>
<term>Infections à Escherichia coli (prévention et contrôle)</term>
<term>Interférence par ARN (MeSH)</term>
<term>Interleukine-6 (métabolisme)</term>
<term>Lipopolysaccharides (pharmacologie)</term>
<term>Macrophages péritonéaux (anatomopathologie)</term>
<term>Macrophages péritonéaux (effets des médicaments et des substances chimiques)</term>
<term>Macrophages péritonéaux (immunologie)</term>
<term>Macrophages péritonéaux (microbiologie)</term>
<term>Macrophages péritonéaux (métabolisme)</term>
<term>Modèles animaux de maladie humaine (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Médiateurs de l'inflammation (métabolisme)</term>
<term>Phagocytose (effets des médicaments et des substances chimiques)</term>
<term>Pipéridines (pharmacologie)</term>
<term>Souris (MeSH)</term>
<term>Souris de lignée C57BL (MeSH)</term>
<term>Sérine-thréonine kinases TOR (métabolisme)</term>
<term>Transduction du signal (effets des médicaments et des substances chimiques)</term>
<term>Transfection (MeSH)</term>
<term>Transporteur-1 d'acides aminés neutres à longue chaîne (génétique)</term>
<term>Transporteur-1 d'acides aminés neutres à longue chaîne (métabolisme)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Large Neutral Amino Acid-Transporter 1</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Amino Acids</term>
<term>Fusion Regulatory Protein 1, Heavy Chain</term>
<term>Inflammation Mediators</term>
<term>Interleukin-6</term>
<term>Large Neutral Amino Acid-Transporter 1</term>
<term>Multiprotein Complexes</term>
<term>TOR Serine-Threonine Kinases</term>
<term>Tumor Necrosis Factor-alpha</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Alkaloids</term>
<term>Anti-Bacterial Agents</term>
<term>Benzodioxoles</term>
<term>Lipopolysaccharides</term>
<term>Piperidines</term>
<term>Polyunsaturated Alkamides</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Infections à Escherichia coli</term>
<term>Macrophages péritonéaux</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Apoptosis</term>
<term>Escherichia coli</term>
<term>Immunity, Innate</term>
<term>Macrophage Activation</term>
<term>Macrophages, Peritoneal</term>
<term>Phagocytosis</term>
<term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Activation des macrophages</term>
<term>Apoptose</term>
<term>Escherichia coli</term>
<term>Immunité innée</term>
<term>Macrophages péritonéaux</term>
<term>Phagocytose</term>
<term>Transduction du signal</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Transporteur-1 d'acides aminés neutres à longue chaîne</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Escherichia coli</term>
<term>Infections à Escherichia coli</term>
<term>Macrophages péritonéaux</term>
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<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Escherichia coli</term>
<term>Escherichia coli Infections</term>
<term>Macrophages, Peritoneal</term>
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<term>Macrophages, Peritoneal</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Infections à Escherichia coli</term>
<term>Macrophages péritonéaux</term>
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<term>Macrophages, Peritoneal</term>
</keywords>
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<term>Chaine lourde de l'antigène CD98</term>
<term>Complexes multiprotéiques</term>
<term>Facteur de nécrose tumorale alpha</term>
<term>Infections à Escherichia coli</term>
<term>Interleukine-6</term>
<term>Macrophages péritonéaux</term>
<term>Médiateurs de l'inflammation</term>
<term>Sérine-thréonine kinases TOR</term>
<term>Transporteur-1 d'acides aminés neutres à longue chaîne</term>
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<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Escherichia coli</term>
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<term>Macrophages, Peritoneal</term>
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<term>Amides gras polyinsaturés N-alkylés</term>
<term>Antibactériens</term>
<term>Benzodioxoles</term>
<term>Lipopolysaccharides</term>
<term>Pipéridines</term>
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</keywords>
<keywords scheme="MESH" qualifier="prévention et contrôle" xml:lang="fr"><term>Infections à Escherichia coli</term>
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<term>Disease Models, Animal</term>
<term>Female</term>
<term>HeLa Cells</term>
<term>Humans</term>
<term>Male</term>
<term>Mechanistic Target of Rapamycin Complex 1</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
<term>RAW 264.7 Cells</term>
<term>RNA Interference</term>
<term>Time Factors</term>
<term>Transfection</term>
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<term>Cellules HeLa</term>
<term>Cellules RAW 264.7</term>
<term>Complexe-1 cible mécanistique de la rapamycine</term>
<term>Facteurs temps</term>
<term>Femelle</term>
<term>Humains</term>
<term>Interférence par ARN</term>
<term>Modèles animaux de maladie humaine</term>
<term>Mâle</term>
<term>Souris</term>
<term>Souris de lignée C57BL</term>
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<front><div type="abstract" xml:lang="en">Pepper, a daily-used seasoning for promoting appetite, is widely used in folk medicine for treating gastrointestinal diseases. Piperine is the major alkaloid in pepper and possesses a wide range of pharmacological activities. However, the mechanism for linking metabolic and medicinal activities of piperine remains unknown. Here we report that piperine robustly boosts mTORC1 activity by recruiting more system L1 amino acid transporter (SLC7A5/SLC3A2) to the cell membrane, thus promoting amino acid metabolism. Piperine-induced increase of mTORC1 activity in resident peritoneal macrophages (pMΦs) is correlated with enhanced production of IL-6 and TNF-α upon LPS stimulation. Such an enhancement of cytokine production could be abrogated by inhibitors of the mTOR signaling pathway, indicating mTOR's action in this process. Moreover, piperine treatment protected resident pMΦs from bacterium-induced apoptosis and disappearance, and increased their bacterial phagocytic ability. Consequently, piperine administration conferred mice resistance against bacterial infection and even sepsis. Our data highlight that piperine has the capacity to metabolically reprogram peritoneal resident macrophages to fortify their innate functions against bacterial infection. </div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26439699</PMID>
<DateCompleted><Year>2016</Year>
<Month>08</Month>
<Day>12</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>11</Month>
<Day>13</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1949-2553</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>6</Volume>
<Issue>32</Issue>
<PubDate><Year>2015</Year>
<Month>Oct</Month>
<Day>20</Day>
</PubDate>
</JournalIssue>
<Title>Oncotarget</Title>
<ISOAbbreviation>Oncotarget</ISOAbbreviation>
</Journal>
<ArticleTitle>Piperine metabolically regulates peritoneal resident macrophages to potentiate their functions against bacterial infection.</ArticleTitle>
<Pagination><MedlinePgn>32468-83</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.18632/oncotarget.5957</ELocationID>
<Abstract><AbstractText>Pepper, a daily-used seasoning for promoting appetite, is widely used in folk medicine for treating gastrointestinal diseases. Piperine is the major alkaloid in pepper and possesses a wide range of pharmacological activities. However, the mechanism for linking metabolic and medicinal activities of piperine remains unknown. Here we report that piperine robustly boosts mTORC1 activity by recruiting more system L1 amino acid transporter (SLC7A5/SLC3A2) to the cell membrane, thus promoting amino acid metabolism. Piperine-induced increase of mTORC1 activity in resident peritoneal macrophages (pMΦs) is correlated with enhanced production of IL-6 and TNF-α upon LPS stimulation. Such an enhancement of cytokine production could be abrogated by inhibitors of the mTOR signaling pathway, indicating mTOR's action in this process. Moreover, piperine treatment protected resident pMΦs from bacterium-induced apoptosis and disappearance, and increased their bacterial phagocytic ability. Consequently, piperine administration conferred mice resistance against bacterial infection and even sepsis. Our data highlight that piperine has the capacity to metabolically reprogram peritoneal resident macrophages to fortify their innate functions against bacterial infection. </AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Pan</LastName>
<ForeName>Hao</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Department of Immunobiology, College of Life Science and Technology, Jinan University, Guangzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Xu</LastName>
<ForeName>Li-Hui</ForeName>
<Initials>LH</Initials>
<AffiliationInfo><Affiliation>Department of Cell Biology, College of Life Science and Technology, Jinan University, Guangzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Huang</LastName>
<ForeName>Mei-Yun</ForeName>
<Initials>MY</Initials>
<AffiliationInfo><Affiliation>Department of Immunobiology, College of Life Science and Technology, Jinan University, Guangzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zha</LastName>
<ForeName>Qing-Bing</ForeName>
<Initials>QB</Initials>
<AffiliationInfo><Affiliation>Department of Fetal Medicine, the First Affiliated Hospital of Jinan University, Guangzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhao</LastName>
<ForeName>Gao-Xiang</ForeName>
<Initials>GX</Initials>
<AffiliationInfo><Affiliation>Department of Immunobiology, College of Life Science and Technology, Jinan University, Guangzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hou</LastName>
<ForeName>Xiao-Feng</ForeName>
<Initials>XF</Initials>
<AffiliationInfo><Affiliation>Department of Immunobiology, College of Life Science and Technology, Jinan University, Guangzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Shi</LastName>
<ForeName>Zi-Jian</ForeName>
<Initials>ZJ</Initials>
<AffiliationInfo><Affiliation>Department of Fetal Medicine, the First Affiliated Hospital of Jinan University, Guangzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lin</LastName>
<ForeName>Qiu-Ru</ForeName>
<Initials>QR</Initials>
<AffiliationInfo><Affiliation>Department of Immunobiology, College of Life Science and Technology, Jinan University, Guangzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ouyang</LastName>
<ForeName>Dong-Yun</ForeName>
<Initials>DY</Initials>
<AffiliationInfo><Affiliation>Department of Immunobiology, College of Life Science and Technology, Jinan University, Guangzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>He</LastName>
<ForeName>Xian-Hui</ForeName>
<Initials>XH</Initials>
<AffiliationInfo><Affiliation>Department of Immunobiology, College of Life Science and Technology, Jinan University, Guangzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Oncotarget</MedlineTA>
<NlmUniqueID>101532965</NlmUniqueID>
<ISSNLinking>1949-2553</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000470">Alkaloids</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000596">Amino Acids</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000900">Anti-Bacterial Agents</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D052117">Benzodioxoles</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D027282">Fusion Regulatory Protein 1, Heavy Chain</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D018836">Inflammation Mediators</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D015850">Interleukin-6</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D027283">Large Neutral Amino Acid-Transporter 1</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D008070">Lipopolysaccharides</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D046912">Multiprotein Complexes</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D010880">Piperidines</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D053284">Polyunsaturated Alkamides</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C523212">Slc3A2 protein, mouse</NameOfSubstance>
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<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D014409">Tumor Necrosis Factor-alpha</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C577686">interleukin-6, mouse</NameOfSubstance>
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<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C440499">lipopolysaccharide, Escherichia coli O111 B4</NameOfSubstance>
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<Chemical><RegistryNumber>EC 2.7.1.1</RegistryNumber>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D000470" MajorTopicYN="N">Alkaloids</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000596" MajorTopicYN="N">Amino Acids</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000900" MajorTopicYN="N">Anti-Bacterial Agents</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017209" MajorTopicYN="N">Apoptosis</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D052117" MajorTopicYN="N">Benzodioxoles</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004195" MajorTopicYN="N">Disease Models, Animal</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004926" MajorTopicYN="N">Escherichia coli</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000472" MajorTopicYN="N">pathogenicity</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004927" MajorTopicYN="N">Escherichia coli Infections</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
<QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D027282" MajorTopicYN="N">Fusion Regulatory Protein 1, Heavy Chain</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006367" MajorTopicYN="N">HeLa Cells</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007113" MajorTopicYN="N">Immunity, Innate</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018836" MajorTopicYN="N">Inflammation Mediators</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015850" MajorTopicYN="N">Interleukin-6</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D027283" MajorTopicYN="N">Large Neutral Amino Acid-Transporter 1</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008070" MajorTopicYN="N">Lipopolysaccharides</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008262" MajorTopicYN="N">Macrophage Activation</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017737" MajorTopicYN="N">Macrophages, Peritoneal</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000076222" MajorTopicYN="N">Mechanistic Target of Rapamycin Complex 1</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008810" MajorTopicYN="N">Mice, Inbred C57BL</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D046912" MajorTopicYN="N">Multiprotein Complexes</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010587" MajorTopicYN="N">Phagocytosis</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010880" MajorTopicYN="N">Piperidines</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D053284" MajorTopicYN="N">Polyunsaturated Alkamides</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000067996" MajorTopicYN="N">RAW 264.7 Cells</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D034622" MajorTopicYN="N">RNA Interference</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058570" MajorTopicYN="N">TOR Serine-Threonine Kinases</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014162" MajorTopicYN="N">Transfection</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014409" MajorTopicYN="N">Tumor Necrosis Factor-alpha</DescriptorName>
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</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Immune response</Keyword>
<Keyword MajorTopicYN="N">Immunity</Keyword>
<Keyword MajorTopicYN="N">Immunology and Microbiology Section</Keyword>
<Keyword MajorTopicYN="N">SLC7A5/SLC3A2</Keyword>
<Keyword MajorTopicYN="N">bacterial infection</Keyword>
<Keyword MajorTopicYN="N">mTORC1</Keyword>
<Keyword MajorTopicYN="N">peritoneal macrophages</Keyword>
<Keyword MajorTopicYN="N">piperine</Keyword>
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<Day>07</Day>
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<Month>09</Month>
<Day>12</Day>
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	Serveur d'exploration sur la rapamycine et les champignons
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Serveur d'exploration sur la rapamycine et les champignons

Piperine metabolically regulates peritoneal resident macrophages to potentiate their functions against bacterial infection.

Piperine metabolically regulates peritoneal resident macrophages to potentiate their functions against bacterial infection.

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